Background Successful endodontic treatment requires a significant knowledge of root canal anatomy. The aim of this study was to evaluate the root and root canal number of permanent teeth among the Moscow population using cone-beam computed tomography (CBCT) scanning. Materials and methods 300 CBCT images of subjects were analyzed to study the anatomy of roots and root canal system of each tooth. The collected data were analyzed using IBM SPSS statistics software 22.0 version. Results The maxillary incisors and canines had one root with one canal in 100%. Maxillary premolars had one root with one or two canals and two roots with two canals, while mandibular premolars were single-rooted with one or two canals. Maxillary first and second molar had three separated roots, and the prevalence of four canals was more often in first molars. Mandibular molars had two roots with different number of canals. Conclusion The root canal system varies greatly among populations and even in different individuals within the same population; thus, using CBCT scanning is an effective technique in investigating the root canal system.

Background: The relationship between the maxillary sinus (MS) and the root apices of the posterior teeth is of clinical relevance in diagnosing and treatment planning in the posterior area of the maxilla. This study aimed to assess the relationship between the MS floor and the root apices of the posterior teeth using cone-beam computed tomography (CBCT) scanning. Materials and Methods: 325 CBCT scans of patients aged 20–70 years were analyzed. Patients were divided into three age groups: young group (20–44 years), middle age group (45–59 years), and elderly group (60–70). The distance from the MS floor and the root apices of posterior teeth was measured in each group. The relationship between the MS and the posterior roots was also recorded according to Kwak classification. The results were analyzed by IBM statistic SPSS. Results: Type II was most commonly seen in the first and second molars. For premolars, Type I was often observed. The shortest distance to the floor of MS was recorded for the mesiobuccal root of the second molar and the longest distance for the palatal root of the first and second molars. No statistical differences were found between age groups ( P > 0.01). Conclusion: The anatomical relationship between the MS and the root apices of the posterior teeth is of clinical importance and should be taken into consideration during surgical or endodontic treatment.

Objectives The aim of this study was to determine the correlation between the state of anxiety (S-anxiety and T-anxiety based on the state–trait anxiety inventory [STAI] test) and the manifestation of dentophobia with changes in salivary pH. Materials and Methods The data of 105 patients, aged 18 to 23 were considered. The student’s anxiety levels were evaluated by the STAI test and they were distributed into three groups. To determine dental anxiety, Corah’s dental anxiety scale (CDAS) testing was performed. To determine the changes in salivary pH, samples were obtained, and pH level of the collected whole saliva was evaluated immediately using pHSCAN 5.4–10.0 litmus paper and a scale in 0.1 to 0.4 increments. Statistical significance was set at 0.05. Results Group I experienced a low level of anxiety and included 33 students (31.4%). Group II comprised of 32 (30.5%) students presenting with a moderate level of anxiety. In group III, 40 students (38.1%) were having a high level of anxiety. Out of the 105 participants, 85% of students showed low level of dentophobia, 27% of them showed a low level of anxiety, 29% showed moderate level of anxiety, and 28% showed high level of anxiety. The average salivary pH value among all the participants (105 students) at rest was 6.79 and in a state of anxiety 6.43. Conclusion within the limits of this study, a correlation was found between the anxiety level and the salivary pH level. Furthermore, a change in the salivary pH toward acidity was registered in each group of students when in a stressful situation.

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The goal of this study was to assess how PD-L1 expression in tissue specimens of patients with main molecular subtypes of NMIBC (luminal, basal and double-negative p53-mutant) associates with relapsed-free survival in dependence on the tumor grade and prior treatment of primary bladder cancer. PD-L1 expressions on the membrane of neoplastic and CD8+ immune cells were assessed in tumor specimens (n = 240) of primary and relapsed luminal, basal and double-negative p53-mutant NMIBC. Association between relapse-free survival and PD-L1 expression was estimated for high- and low-grade relapsed NMIBC according to previous treatment and their molecular profile, using the Kaplan–Meier method, and assessed by using the log-rank test. Potential confounders were adjusted by Cox regression models. In a group of patients who underwent only TUR without intravesical therapy, there were significant differences in relapse time between high- and low-grade tumors in basal and luminal molecular subtypes; for basal relapsed carcinoma, RFS was shorter in cases where tumors were less malignant. Both intravesical mitomycin and Bacillus Calmette–Guerin (BCG) therapy significantly extended the time of recurrence of low-grade luminal and basal bladder malignancies with no intergroup differences in double-negative NMIBC. PD-L1 expression status was associated with RFS for luminal relapsed NMIBCs in the group without previous frontline intervention, and with RFS in the group of patients with luminal relapsed bladder cancer previously utilized BCG. Obtained results may be considered as a promising approach for further clinical implementation.