Background Mass vaccination of the global population against the novel COVID-19 outbreak posed multiple challenges, including effectively administering millions of doses in a short period of time while ensuring public safety and accessibility. The government of Dubai launched a mass campaign in December 2020 to vaccinate all its citizens and residents, targeting the population aged >18 years against COVID-19. The vaccination campaign involved a transformation of multiple commercial spaces into mass vaccination centers across the city of Dubai, the largest of which was the Dubai One Central (DOC) vaccination center. It was operational between January 17, 2021, and 27 January 27, 2022. Objective The multiphase research study aims to empirically explore the opinions of multiple health care stakeholders, elicit the key success factors that can influence the effective delivery of emergency health care services such as a COVID-19 mass vaccination center, and explore how these factors relate to one another. Methods To understand more about the operations of the DOC vaccination center, the study follows a multiphase design divided into 2 phases. The study is being conducted by the Institute for Excellence in Health Professions Education at Mohammed Bin Rashid University of Medicine and Health Sciences between December 2021 and January 2023. To elicit the key success factors that contributed to the vaccination campaign administered at DOC, the research team conducted 30 semistructured interviews (SSIs) with a sample of staff and volunteers who worked at the DOC vaccination center. Stratified random sampling was used to select the participants, and the interview cohort included representatives from the management team, team leaders, the administration and registration team, vaccinators, and volunteers. A total of 103 people were invited to take part in the research study, and 30 agreed to participate in the SSIs. To validate the participation of various stakeholders, phase 2 will analytically investigate one’s subjectivity through Q-methodology and empirically investigate the opinions obtained from the research participants during phase 1. Results As of July 2022, 30 SSIs were conducted with the research participants. Conclusions The study will provide a comprehensive 2-phase approach to obtaining the key success factors that can influence the delivery of high-quality health care services such as emergency services launched during a global pandemic. The study’s findings will be translated into key factors that could support designing future health care services utilizing evidence-based practice. In line with future plans, a study will use data, collected through the DOC vaccination center, to develop a simulation model outlining the process of the customer journey and center workflow. International Registered Report Identifier (IRRID) DERR1-10.2196/42278

BACKGROUND Mass vaccination of the global population posed multiple challenges, including effectively administering millions of doses in a short period while ensuring public safety and accessibility. The Government of Dubai launched a mass campaign to vaccinate all its citizens and residents in December 2020. The campaign involved a transformation of commercial spaces into mass vaccination centers (MVCs), the largest of which was the Dubai One Central (DOC) Vaccination Center. It was operational between 17 January 2021 and 27 January 2022. OBJECTIVE The multi-phase research study aims to empirically explore the opinions of multiple healthcare stakeholders, elicit the key success factors that can influence the effective delivery of healthcare services such as COVID-19 MVCs, and explore how these factors correlate to one another. METHODS To understand more about Dubai One Central’s vaccination campaign, the study follows a multi-phase design divided into two main sections. To elicit the key success factors that contributed to the vaccination campaign administered at DOC, the research team conducted 30 semi-structured interviews (SSI) with a sample of staff and volunteers who worked at the DOC vaccination center. Stratified random sampling was used to select the participants, and the interview cohort included representatives from the management team, team leaders, administration and registration team, vaccinators, and volunteers. A total of 103 people were invited to participate in the research study, and 30 accepted to participate in the SSI interviews. To validate the participation of various stakeholders, the second phase analytically investigated one’s subjectivity through Q-methodology and empirically investigating the opinions obtained from the research participants during phase 1. RESULTS As of July 2022, 30 semi-structured interviews were conducted with the research participants. The expected results from the project's first phase will be identifying key success factors, enablers, and barriers of the design and operation of the Covid-19 vaccination center at DOC. While the expected results from the study's second phase will identify patterns of similarities and differences in the ranking of the Q-sets. The final set of results from this dataset will quantitatively interpret the common answers amongst participants and the correlation between the selected success factors relating to the study. CONCLUSIONS In conclusion, the study will provide a comprehensive approach to obtaining the key success factors that can influence the delivery of high-quality healthcare services, which can be optimized to suit the purpose of its design. The study's findings will be translated into key factors that could support designing future health services utilizing evidence-based practice.

Obesity is a complex multifactorial disorder involving the differentiation of pre-adipocytes to mature adipocytes which is achieved through the process of adipogenesis via interaction with different adipogenic transcription factors and mediators. Many drugs and their interactions has been implicated with the common feature of adipose tissue enlargement through hyperplasia and hypertrophy. Caffeine and Paracetamol are few of the most common used drugs which have been theorized by previous researches to have some influence on the adipogenic process. In our study, we investigated the effects of Caffeine, Paracetamol and β-Naphthoflavone on the differentiation of Human Adipose Derived Mesenchymal Stem Cells (HAD-MSC). Cells were cultured in vitro using differentiation inducing media with and without the presence of different combinations of the drugs. Biochemical markers of adipogenesis were evaluated using biochemical assays for triglyceride and glycerol quantification. Our results show that there is an increase of glycerol and triglyceride concentration in cells treated with caffeine suggesting its anti-lipogenesis characteristics through the enhancement of the lipolytic process.Paracetamol also appears to have anti-adipogenic effects due to its apparent role in suppressing the accumulation of triglycerides. In addition, only the use of β-Naphthoflavone in combination with caffeine and Paracetamol, resulted in lower triglyceride concentrations than the latter two drugs alone which may indicate its possible enhancing anti-adipogenic properties is through its interaction with the other two drugs.