Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is a viral pathogen that causes coronavirus disease 2019 (COVID-19). Angiotensin-converting enzyme 2 (ACE2), as a receptor, is crucial for SARS-CoV-2 to get access into the host cells. According to reports, ACE2 is expressed in the liver, placenta, heart, lungs and kidneys. This study sought to gain unique insights into the features of liver indicators in individuals suffering from COVID-19 disease in order to enhance their therapeutic care. The study groups included 50 people diagnosed with COVID-19 infection in the patient's group and 25 healthy people without any systemic diseases in the control group. Human serum samples were used to measure liver function enzymes, CRP, D dimer, and ferritin all samples by using automated quantitative tests. The results revealed a statically significant difference between AST, ALP, TSB, and study groups, where it is found that the mean levels of AST (88.04±33.00) and ALP (99.61±41.93) were high in patients than in controls, while the mean levels of TSB were low in patients (0.51±0.21) than the controls. A significant difference was also obtained for each ferritin, CRP, and D dimer between the study groups, where it found the mean concentrations of D dimer, ferritin and CRP, i.e., 1208.09±667.32, 60.53±23.91 and 204.52±90.62, respectively, were high in the patient's group than in controls.