Microbial activity can lead to problems such as corroded tubing, formation plugging, and decreased effective permeability, especially the sulfate-reducing bacteria that have the formation water as a medium that allows their proliferation. These adhere to the conductive channels of the producing sand and form biomass that restricts the flow of fluids. This work was carried out to design a non-reactive matrix stimulation by injecting biocides that clean the sand face to increase permeability, reduce formation damage, control corrosive environments, and increase daily oil production. By analyzing the total concentration of iron, sulfate, carbon dioxide, sulfide in gas and water, wells with microbial activity were identified, while the behavior of the bacteria was characterized by evaluating bacterial cultures and corrosion coupons. Using economic profitability criteria, the TTT A 011 and TAP 09 wells were selected as the most prospective in the Libertador field since, out of the 94 wells analyzed, they presented the highest index of microbial activity and recovery of oil barrels. The microbial activity in the wells of the Tetete station is more aggressive, since they reproduce in less time, clogging the porous channels at a faster rate. The THPS and GLH bactericides had better functionality against bacteria and the environment, so they were considered in this design of non-reactive matrix stimulation generating $907,976.10 as profit for the company in the 12-month projection.