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This study aimed to investigate the biochemical and histopathological effects of curcumin on Renal Ischemia/Reperfusion Injury. Twenty-four female Wistar rats were used in the study and divided into control (C), sham, ischemia/reperfusion (I/R), and curcimin (CUR) groups (n=6). Laparotomy was performed under general anesthesia in I/R and CUR groups than the left renal pedicle was dissected it was clamped. Then, 1-h ischemia and 6-h reperfusion were applied. 500 mg/kg Curcumin was given intraperitoneally to the CUR group after ischemia application. MPO, IMA, MDA, NO, SOD, GPx, AOS, urea, and creatinine levels were measured in serum samples. MPO, MDA, NO, SOD, GPx, and AOS were also measured in tissue samples. The histopathological examination was performed. Serum and tissue AOS levels were significantly higher in the CUR group than in the I/R group (P<0.05). Tissue NO levels were significantly lower in the CUR group than in the I/R group (15.30±5.41 and 4.8±1.37, respectively) (P<0.05). Histopathological scores were also significantly lower in the CUR group than in the I/R group (P<0.05). The results showed that curcumin prevented I/R damage by decreasing oxidative stress in serum and tissue samples in rat renal I/R model.

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