ABSRACTVaginal candidiasis (VC) is second to bacterial vaginitis, as the most common opportunistic mucosal infection that affects large numbers of otherwise healthy women of childbearing age. The incidence of VC is significantly modified by dressing patterns and aberrant health-care practices. Contemporary young women often shift their preference from skirt to trousers and leggingswhich also coincides with a rise in auto-medication and over-the-counter drugs phenomena in our communities. These could result in increased occurrence of vaginal candidiasis infection and antifungal drug resistance. This was a cross-sectional study conducted between March 2011 and August 2011 among150 female students(aged 17-29 years) of the University of Buea.Socio-demographics information, risk factors and clinical symptoms were gotten through a standard questionnaire. Vaginal swabs were collected from each participant and cultured on Sabouraud'sdextrose agar supplemented with chloramphenicol (SDA-CAF). Identification and antifungal susceptibility testing was performed following standard microbiological procedures. Of the 150 participants who submitted vaginal swabs, yeasts was isolated in 98 (65.3%). Of the 98 yeasts isolates, 73.5% were Candida species, mainly C. albicans (65.3%). Overhalf (64.7%) ofstudyparticipantshadapreferencefortrousers,however, this attitude was not significantly associated (p = 0.559) with candidiasis.Previous episodes of vaginal infection and treatment for candidiasis were significantly associated with VC (p = 0.004). Antifungal susceptibility results showed a high resistance to fluconazole (82.0%), nystatin (80.0%) and ketoconazole (72.0%), while clotrimazole (50.0%) was the most activeantifungal drug. There was a high prevalence of VC in this study population with previous vaginal infectionbeing important risk factor for reoccurrence. Clotrimazole was the drug of choice in the treatment of VC in this population. Key words: vaginal candidiasis, risk factors, antifungal susceptibility profiles PROFILS DE SENSIBILITE AUX ANTIFONGIQUES ET FACTEURS DE RISQUE DE CANDIDOSE VAGINALE CHEZ LES ETUDIANTES UNIVERSITAIRES AU SUD-OUEST DU CAMEROON TITRE COURANT:PROFILS DE SENSIBILITE AUX ANTIFONGIQUES ET FACTEURS DE RISQUE DE CANDIDOSE VAGINALE CHEZ LES ETUDIANTES UNIVERSITAIRESLa candidose vaginale (CV) est la deuxième infection opportuniste de la muqueuse la plus fréquente (après la vaginite bactérienne) qui affecte un grand nombre de femmes en âge de procréer. L'incidence de la CV est affectée de façon significative par certaines habitudes vestimentaires et pratiques