JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org. This content downloaded from 130.102.42.98 on Mon, SUMMARY(1) Bulinus globosus populations were sampled weekly in two reservoirs over 2 years, using plastic sheet snail traps and mark recapture techniques to measure density, growth rates and reproduction.(2) Captive cohorts were raised in netted boxes in the reservoirs to measure age specific reproduction and egg viability.(3) Growth rates were used to identify snail cohorts, and life tables were constructed to measure mortality rates and the intrinsic rate of natural increase (rm).(4) Values for ri were inversely related to mean water temperatures, with no positive values when the mean water temperature exceeded 28-5 'C during a cohort's early reproductive phase.(5) Rainfall (and associated environmental variables) appear to influence the carrying capacity of the snail habitat, so that in both reservoirs, populations increased fastest and to the highest densities when large amounts of unseasonal rain fell during the coolest months.

A total of 168 fully polarimetric synthetic-aperture radar (SAR) images are selected together with the buoy measurements of ocean surface wind fields and high-frequency radar measurements of ocean surface currents. Our objective is to investigate the effect of the ocean currents on the retrieved SAR ocean surface wind fields. The results show that, compared to SAR wind fields that are retrieved without taking into account the ocean currents, the accuracy of the winds obtained when ocean currents are taken into account is increased by 0.2-0.3 m/s; the accuracy of the wind direction is improved by 3-4 • . Based on these results, a semi-empirical formula for the errors in the winds and the ocean currents is derived. Verification is achieved by analysis of 52 SAR images, buoy measurements of the corresponding ocean surface winds, and high-frequency radar measurements of ocean currents. Results of the comparisons between data obtained by the semi-empirical formula and data measured by the high-frequency radar show that the root-mean-square error in the ocean current speed is 12.32 cm/s and the error in the current direction is 6.32 • .

To study the electromagnetic backscattering from a one-dimensional drifting fractal sea surface, a fractal sea surface wave-current model is derived, based on the mechanism of wave-current interactions. The numerical results show the effect of the ocean current on the wave. Wave amplitude decreases, wavelength and kurtosis of wave height increase, spectrum intensity decreases and shifts towards lower frequencies when the current occurs parallel to the direction of the ocean wave. By comparison, wave amplitude increases, wavelength and kurtosis of wave height decrease, spectrum intensity increases and shifts towards higher frequencies if the current is in the opposite direction to the direction of ocean wave. The wavecurrent interaction effect of the ocean current is much stronger than that of the nonlinear wave-wave interaction. The kurtosis of the nonlinear fractal ocean surface is larger than that of linear fractal ocean surface. The effect of the current on skewness of the probability distribution function is negligible. Therefore, the ocean wave spectrum is notably changed by the surface current and the change should be detectable in the electromagnetic backscattering signal.

The rapid development of urbanization and population growth in China has posed a major threat to the green sustainable development of the ecological environment. However, the impact of urbanization on the eco-environmental quality (EEQ) in China remains to be developed. Understanding their interactive coupling mechanism is of great significance to achieve the urban sustainable development goals. By using multi-source remote sensing data and the coupling coordination degree model (CCDM), we intended to answer the question “What are the temporal and spatial characteristics of urbanization and EEQ in China on the pixel scale during 2000–2013, and what is the coupling mechanism between the urbanization and the EEQ?”. To answer these questions, we explored the coupling mechanism between urbanization and the EEQ in China with a combined mathematical and graphics model. The results show that the urbanization and the coupling coordination degree (CCD) of the whole region continually increased from 2000 to 2013, especially in the three major urban agglomerations, with a spatial distribution pattern that was “high in the east and low in the west”. Most importantly, from 2000 to 2013, the CCD type of cities in China gradually evolved from uncoordinated cities to coordinated cities. Additionally, the decisive factor affecting the CCD from 2000 to 2013 was the development of urbanization, and the degree at which urbanization had an impact on CCD was about 8.4 times larger than that of the EEQ. At the same time, the rapid urbanization that has occurred in some areas has led to a significant decline in the EEQ, thus indicating that China needs to increase its protection of the ecological environment while pursuing social and economic development in the future. This study makes up for the deficiencies in the existing literature and investigates the long-term coupling of the EEQ and urbanization in China, thereby providing a new research perspective for the sustainable development of China and even the world in the future.

The discovery of a potent selective low dose Janus kinase 1 (JAK1) inhibitor suitable for clinical evaluation is described. As part of an overall goal to minimize dose, we pursued a medicinal chemistry strategy focused on optimization of key parameters that influence dose size, including lowering human Cl and increasing intrinsic potency, bioavailability, and solubility. To impact these multiple parameters simultaneously, we used lipophilic ligand efficiency as a key metric to track changes in the physicochemical properties of our analogs, which led to improvements in overall compound quality. In parallel, structural information guided advancements in JAK1 selectivity by informing on new vector space, which enabled the discovery of a unique key amino acid difference between JAK1 (Glu966) and JAK2 (Asp939). This difference was exploited to consistently produce analogs with the best balance of JAK1 selectivity, efficacy, and projected human dose, ultimately culminating in the discovery of compound 28.