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The study draws attention to the importance of considering and controlling for caffeine and the interactive effects between caffeine and alcohol when investigating aggressive and violent behavior. Various pathways between caffeine and alcohol consumption and aggression and violence are examined. Given recent changes in preferences and availability of caffeine and energy drinks among licit and illicit substance users, this study argues for the importance of focusing research attention on the role of caffeine, particularly when combined with alcohol, in facilitating violent outcomes. Evidence suggests that both caffeine and alcohol are linked to aggression and violence and that both substances should be considered within the context of our efforts to manage the negative consequences of drugs. Caffeine, via energy drink consumption, may contribute to violent offending and victimization in a variety of ways. Evidence suggests that caffeine/energy drink consumption is popular among a subculture of toxic jock users, may motivate and facilitate increased alcohol consumption particularly in late night-time economies, and can potentially contribute to disrupted decision-making. Recent increases in caffeinated-product availability, marketing, and consumption necessitate focused research and policy attention. Many of these products are consumed with alcohol and/or in late evening settings by individuals that are already at increased risk for violent offending and victimization.