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Background: Hyperglycemia was found to cause multiple adverse effects on myocardial muscle as it induces oxidative stress, apoptosis, enhances inflammation, and activates coagulation, which deteriorates myocardial damage in the setting of ischemia. Objective: Assess the impact of acute and chronic hyperglycemia on In-hospital and short term "6 months" outcomes in patients with acute myocardial infarction. And the effect of hyperglycemia on left ventricular remodeling using speckle-tracking echocardiography. Subject and methods: The final study population was 100 patients who were divided according to: A) Admission plasma glucose, they were classified into 2 groups: Non acute group: including 77 patients with RBS (< 200 mg/dl) and Acute group: including 23 patients with RBS (≥ 200 mg/dl). B) Glycated hemoglobin (HbA1c), also cases were classified into another (2) groups: Non chronic group: including 64 patients with normal HbA1c (< 6.5) and Chronic group: including 36 patients with elevated HbA1c (≥ 6.5). Result: From the echocardiographic finding in patients with and without acute-HG and in patients with and without chronic-HG, we can say that the increased values of EDV, ESV, E wave, WMSI and E/A ratio, along with decreased values of EF, ś and A wave (parameters of worsening diastolic and myocardial systolic function) in the patients with acute-HG in comparison with the patients without acute-HG, indicates that acute-HG is associated with adverse effects on LV functions, mainly progressive diastolic dysfunction and deterioration of pumping function of the heart (LV remodeling) . Regarding the GLS, our results showed that patients with both acute and chronic HG were having worse GLS in comparison with those

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