Background: SLE is a complex autoimmune disease with heterogenous clinical manifestations and disease course, Nephritis is a major cause of morbidity and mortality in patients with lupus. Many clinical parameters and laboratory markers can be used to evaluate disease activity. NLR is positively associated with inflammatory disorders.Objectives: Is to evaluate the Neutrophil Lymphocytic ratio (NLR) as a reliable predictive and prognostic marker in systemic lupus erythematosus.Methods: The present study was carried out on 60 patients and 20 healthy individuals as controls. Patients were classified into: Group I: 40 SLE patients with active disease, which was sub divided into two subgroups: Group IA included thirty SLE patients with LN and Group IB included ten SLE patients with active disease without nephritis. Group II: 20 SLE patients with inactive disease. Group III: 20 apparently healthy volunteers as controls. CBC, serum creatinine, ESR, CRP, ANA, Anti-ds DNA, C3, C4, 24-hour protein in urine and urine analysis were done to all participants.Results: The NLR of SLE patients was significantly higher compared to that of the controls. Furthermore, SLE patients with nephritis had higher NLR levels than those without nephritis. Conclusion:NLR is a useful, simple and bed side inflammatory marker for assessment of disease activity in patients with SLE. Also, NLR is a promising predictor of lupus nephritis.