An inexpensive self-made apparatus for photochemical experiments was developed and has been tested to facilitate the inclusion of photoreactions in undergraduate teaching laboratories despite budget constraints. The core setup allowing the selection of defined wavelengths in the visible and UV regions is made of commercially available components for less than $500, including an enclosure providing a high safety standard. By choice of the reaction glassware, both reactions on micro scale as well as on preparative scale can be conducted easily in an appropriate time frame. In the Supporting Information, ideas for further optional equipment expanding the setup and enhancing its applicability are presented.

Die Entwicklung neuer Arzneistoffe ist ein mit Blick auf den Gymnasialunterricht möglicher Kontext mit hohem Lebensweltbezug. Ein Lehrexperiment, basierend auf dem käuflich erhältlichen Modell‐Zielmolekül Trypsin und mehreren Inhibitoren, ist mit in der Schule verfügbaren Methoden auf einfache und robuste Weise durchführbar. Es verdeutlicht den Kern des rationalen Wirkstoffdesigns (rational drug design), nämlich die planvolle Variation der molekularen Struktur zur Erhöhung der Bindungsaffinität an die Substituenten in der Bindetasche des Zielmoleküls, durch Erhöhung der Summe an intermolekularen Wechselwirkungen. Somit wird für Schülerinnen und Schüler nachvollziehbar, wie genau neue Arzneimittel auf molekularer Ebene erdacht bzw. erarbeitet werden.

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The Front Cover shows the revisited photochemistry of butyrophenone. The bright sun and beautiful nature are symbolizing the photons as clean energy source. After excitation, pathways to wander downhill are standing for different deactivation route which the system can undergo. A new reaction pathway is reported. In addition to the Norrish type II fragmentation and Yang cyclization, intermolecular species are generated: 1,2‐Dibenzoylethane and pinacols. They account for approx. 20% of the converted starting material, similar to the Yang product. The authors would like to thank the Provadis School (Frankfurt, emblem shown right) for making this work possible. More information can be found in the Communication by H. Hoffmann and M. W. Tausch.

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