Membrane plasma exchange can be performed by the use of a double-pump hemofiltration device with only one central venous Shaldon catheter. According to this single-needle technique the intermittent blood flow is controlled by pressure monitoring resulting in a continuous filtration flow of 70 m1/min which is quantitatively replaced by an albumin (30 g/l) substitution fluid. Thus, a 4,000-m1 plasma exchange can be performed within 1 h and an equal or even better sieving coefficient for IgG (S = 0.81) is achieved compared with the continuous technique using two vascular accesses.

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