Background Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide. Many individuals have risk factors associated with NAFLD, but the majority do not develop advanced liver disease: cirrhosis, hepatic decompensation, or hepatocellular carcinoma. Identifying people at high risk of experiencing these complications is important in order to prevent disease progression. This review synthesises the evidence on metabolic risk factors and their potential to predict liver disease outcomes in the general population at risk of NAFLD or with diagnosed NAFLD. Methods and findings We conducted a systematic review and meta-analysis of population-based cohort studies. Databases (including MEDLINE, EMBASE, the Cochrane Library, and ClinicalTrials.gov) were searched up to 9 January 2020. Studies were included that reported severe liver disease outcomes (defined as liver cirrhosis, complications of cirrhosis, or liver-related death) or advanced fibrosis/non-alcoholic steatohepatitis (NASH) in adult individuals with metabolic risk factors, compared with individuals with no metabolic risk factors. Cohorts selected on the basis of a clinically indicated liver biopsy were excluded to better reflect general population risk. Risk of bias was assessed using the QUIPS tool. The results of similar studies were pooled, and overall estimates of hazard ratio (HR) were obtained using random-effects meta-analyses. Of 7,300 unique citations, 22 studies met the inclusion criteria and were of sufficient quality, with 18 studies contributing data suitable for pooling in 2 random-effects meta-analyses. Type 2 diabetes mellitus (T2DM) was associated with an increased risk of

This paper explores the concept of collective housing, notably the North American model of purpose-built cohousing, to understand better the functions of space and time at the neglected scale of collective (colocated) interhousehold collaboration. The defming features of this form of intentional community typically include the clustering of smaller-than-average private residences to maximise shared open spaces for social interaction; common facilities for shared daily use; and consensus-based collective self-governance. This paper critically examines the infrastructures of daily life which evolve from, and ease, collective activity and the shared occupation of space. Discussion draws on observations from eight communities in the UK and USA, using selected ethnographic vignettes to illustrate a variety of alternative temporalities which coincide with a shifting and blurring of privatised dwelling. The resulting analysis exposes multiple temporal scales and innovative uses and meanings of time and space. The paper concludes by speculating on the contemporary significance of collective living arrangements and the role this might play in future sustainability.

Chronic use of MDMA (3,4-methylenedioxymethamphetamine), or Ecstasy, is believed to lead to impaired psychological performance, including well-documented decrements in laboratory and field tests of retrospective memory. Less is known about the impact of Ecstasy on aspects of 'everyday' memory, despite obvious concerns about such effects. The three studies reported here focused on the impact of chronic Ecstasy use on prospective memory (PM), associated central executive function and other aspects of day-to-day cognition. In study 1 46 regular Ecstasy users were compared with 46 Ecstasy-free controls using the Prospective Memory Questionnaire (PMQ). Ecstasy users reported significantly more errors in PM (remembering to do something in the future); these findings persisted after controlling for other drug use and the number of strategies used to aid memory. No difference was found between representative subgroups on the Lies Scale of the Eysenck Personality Questionnaire. In study 2 a different group of 30 regular Ecstasy users and 37 Ecstasy-free controls was assessed on the PMQ and on a central executive task comprising verbal fluency measures. The results confirmed the significant impairments in long- and short-term PM and revealed corresponding impairments in verbal fluency. In study 3 15 Ecstasy users, 15 cannabis users and 15 non-drug users were assessed using the Cognitive Failures Questionnaire, which requires participants to provide ratings of the frequency of various day-to-day cognitive slips. The results indicate that the Ecstasy users did not perceive their general cognitive performance to be worse than that of controls. Taken together, these results suggest that Ecstasy users have impaired PM that cannot be explained by an increased propensity to exaggerate cognitive failures. These may be attributable, in part, to central executive deficits that are due to frontal lobe damage associated with Ecstasy use. Copyright 2001 John Wiley & Sons, Ltd.

This paper explores the extensification of work-that is the distribution or exporting of work across different spaces/scales and times-and its impact on individual workers and households. We argue that contracting out and the work life balance debates might be developed more usefully within the holistic framework of extensification. The key process that we follow can be described as overflowing. We contrast the universally positive representations of spillovers and embedding that we are familiar with in economic geographies with the more negatively characterised overflowing of work into and out of the household. The paper is built around a case study of those involved in the new media industry in San Francisco: households, workers and companies.

The connections between home and work are manifest in tensions which exist between individual employment mobility and the social and spatial situatedness of the household micro-economy. This nexus is a significant dimension of a growing number of dual earning households. At a fundamental level, the co-ordination of home and work hinges on opportunities and constraints pertaining to residential location and mobility and the way this issue is negotiated through the life-course. However, this is not simply determined by the many logistical difficulties associated with the co-ordination of more than one employment from a single residential location. Households are `situated' in place in a variety of ways which feed into strategies of relative mobility and attachment to place. It is suggested that the way that households accommodate the demands of home and work are constituted through a meshing together of the action spaces and social relations of individual household members in these spheres. In effect, household behaviour emerges from a `tangled web' of networks: of social and kin relations; of resource provision; and of information, knowledge and learning. This paper argues for the need to attend to the situatedness of household strategies that attempt to co-ordinate home and work. It suggests that this is achieved by observing the way strategies of relative mobility and attachment to place reproduce, and are reproduced through, networks within a locale. Existing concepts of strategy and network are combined and operationalised together through the interpretation of biographical narratives from interviews with couples from a sample of nuclear family households.