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People are vulnerable to mosquito-borne infections in tropical and subtropical climate countries. Due to resistive issues, vector control is an immediate concern in today's environment. The current study describes the synthesis of magnesium oxide by four different approaches including green, microwave, sol−gel, and hydrothermal methods. The synthesized magnesium oxide (MgO) nanoparticles were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), high-resolution scanning electron microscopy (HRSEM), and energy-dispersive X-ray analysis (EDAX) techniques. The FT-IR studies reveal the presence of functional groups in the synthesized nanoparticles. The structural and morphological studies were investigated using XRD and HRSEM. EDAX reveals the presence of Mg and O in the prepared samples. The synthesized MgO NPs were screened for antibacterial studies against Gram-positive strains, Enterococcus faecalis and Staphylococcus aureus, two Gram-negative cultures, Escherichia coli and Klebsiella pneumoniae, using different concentrations. The results indicated excellent antibacterial activity against both Gram-positive and Gram-negative bacteria at 50 mg/mL hydrothermally produced MgO nanoparticles, with a maximal zone of inhibition (ZOI) of 5 mm for S. aureus, 7 mm for E. faecalis, and 6 mm for K. pneumoniae. The ZOI of E. coli was found to be the greatest at 9 mm when 50 mg/mL sol−gel-produced MgO nanoparticles were used. The synthesized MgO nanostructures were tested against fourth-instar larvae of Aedes aegypti and Aedes albopictus, and the hydrothermally synthesized MgO nanostructures exhibited better results when compared with other methods of synthesis. The reports show that A. aegypti and A. albopictus mortality rates were reported to be the lowest with green-manufactured MgO nanoparticles (7.5 g mL −1 ) and the highest with hydrothermally synthesized MgO nanoparticles (120 g mL −1 ). The research indicates that MgO nanostructures are promising drugs for antibacterial and mosquitocidal larvae control properties.

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