No abstract

A series of coupling products have been prepared by a ruthenium(II)‐catalyzed direct ortho‐C–H arylation of 2‐(aryl/heteroaryl)‐substituted quinazolines with (hetero)aryl bromides. Tri(hetero)aryl‐substituted alkenes were also prepared by olefinic C–H activation of 2‐(2‐arylvinyl)quinazoline derivatives. High conversions and selectivities were achieved by choosing the appropriate ruthenium(II) carboxylate catalyst system, solvent, and reaction temperature. The possibility of a C(sp3)–H functionalization by applying an arylation/reduction reaction sequence was also demonstrated.

No abstract

No abstract

The one-pot synthesis of a broad variety of dihydrofuroquinolines, dihydrothienoquinolines, and dihydrobenzoquinolines is reported. The combination of the Rh­(I)-catalyzed hydroarylation of vinylpyridines with the Pd(0)/Pd­(II)-catalyzed direct C–H arylation in a Multicomponent-Multicatalyst Reaction (MC)2R could be used to develop an efficient and step-economic protocol for the rapid construction of molecular complexity. A high-yielding synthesis of π-extended heteroarenes through an efficient three-step-one-pot procedure and a highly enantioselective synthesis of 6-alkylsubstituted dihydrobenzoquinolines are shown.