The tubular reabsorption of Ca has been studied by means of Ca clearance investigations in 16 patients with non endocrine diseases during long term therapy with small doses of corticosteroids. The tubular reabsorption of Ca was reduced in 7 patients. This is attributed to the anti-anabolic action of the corticosteroids on the cells of the tubules. Ca reabsorption became normal on administration of anabolic steroids.

No abstract

During treatment with steroid hormones the tubular reabsorption of citric acid (cit.) increases, and the endogenous citric acid clearance is reduced. This is attributed to increased diffusion of citric acid from the tubular lumen to the renal tissue. With simultaneous administration of corticosteroids and anabolic steroids the tubular reabsorption of citric acid becomes normal. Steroid hormones block the renal synthesis of cit. and the renal utilization of cit. becomes identical with the amount of cit. reabsorbed in the tubules. Blockade of the synthesis of cit. is attributed to the inhibitory effect of steroid hormones on enzyme systems.

No abstract

Among 84 patients with jaundice and liver disease, the Australia‐SH antigen was demonstrated in the serum of ten. Nine of these patients were scored as suffering from serum hepatitis or “possible serum hepatitis”. The last patient who had the Australia‐SH antigen in her serum suffered from chronic hepatitis. The Australia‐SH antigen was not demonstrated in serum of any of the 35 patients with infectious hepatitis. Thus, the present limited data appear to confirm that there is a specific association between serum hepatitis and occurrence of the Australia‐SH antigen, as reported by Prince (1968) and Giles et al. (1969).