Cervical cancer is a serious public health problem in Brazil, especially in Manaus (Amazonas), the city with the highest incidence rate of cervical cancer in the country. Persistent infection with oncogenic human papillomavirus (HPV) genotypes is the cause of disease development. The aim of this study was to investigate the prevalence of oncogenic genotypes in women at high risk for cervical precancer examined in two policlinics in Manaus. One hundred and two patients who underwent colposcopy took part in the research. The DNA samples obtained from the cervical epithelium were analyzed by PCR with type-specific primers for the detection of eight oncogenic genotypes, which were chosen based on previous studies. The presence of HPV virus was detected in all samples. The most prevalent oncogenic genotypes were 18 (47.1%) and 16 (45.1%). Interestingly, HPV 18 was considered uncommon in this region. In addition to these, genotypes 31 (19.6%), 58 (19.6%), 33 (18.6%), and 45 (15.7%) also had a relatively high frequency in this population. Fifty-six women (54.9%) had multiple infections with up to five oncogenic types. Also, the presence of genotypes other than 16 and 18 was observed in most samples (57.8%), which also deserves attention since they are not covered by currently available vaccines against HPV in Brazil. The high prevalence and multiple infections with several oncogenic HPV genotypes in association with precursor lesions for cervical cancer highlighted the need to improve strategies to prevent this disease in Amazonas.

Objetivo: Analisar o perfil epidemiológico e o impacto do sangramento uterino anormal (SUA) na qualidade de vida de pacientes com este sintoma, em ambulatório de ginecologia da cidade de Manaus, de junho a dezembro de 2020. Métodos: Estudo observacional, transversal, prospectivo; dados referentes a identificação, perfil epidemiológico e caracterização do sangramento obtidos por questionário fechado foram tabulados, analisados no SPSS e organizados em tabelas e gráficos no Excel. Resultados: Foram atendidas 60 pacientes com SUA, a maioria entre 40 e 50 anos de idade (45%), escolaridade de nível médio (50%), de cor parda (78,3%), natural e procedente de Manaus (58,3% e 86,7%) com renda familiar média de 1.925 reais. O tempo de evolução dos sintomas foi em média de 11,5 meses. 50% definiram a alteração do padrão menstrual como aumento do fluxo. 56% classificaram sua qualidade de vida entre regular e muito ruim. 46,7% referiram impacto do sangramento no dia a dia e 58,3%, interferência na vida sexual. Conclusão: O SUA interfere negativamente na qualidade de vida feminina com maior ênfase na vida sexual e social. A maioria das mulheres com SUA apresentam aumento do fluxo menstrual. É necessário o desenvolvimento de abordagem individualizada e integral para o tratamento resolutivo.