Accelerated degradation tests are used to provide accurate estimation of lifetime properties of highly reliable products within a relatively short testing time. There data from particular tests at high levels of stress (e. g. temperature, voltage, or vibration) are extrapolated, through a physically meaningful model, to obtain estimates of lifetime quantiles under normal use conditions. In this work, we consider repeated measures accelerated degradation tests with multiple stress variables, where the degradation paths are assumed to follow a linear mixed effects model which is quite common in settings when repeated measures are made. We derive optimal experimental designs for minimizing the asymptotic variance for estimating the median failure time under normal use conditions when the time points for measurements are either fixed in advance or are also to be optimized.

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