Background: TB still a major public health problem. Understanding the knowledge practice and attitude of nurses which may influence TB control is very important for ending TB epidemic. The aim: The present study aims to assess nurses' performance for patients with tuberculosis disease at chest dispensaries in El-Gharbia governorate. Design: A descriptive study design was utilized. Setting: The study was conducted at 7 chest dispensaries in EI-Gharbia governorate, Egypt. Sample: A convenient sample was used composed of 150 nurses working in the previously mentioned setting. Tool: Data were collected using one tool; A structured Interviewing questionnaire consists of 5 parts; (1) Socio-demographic characteristics of nurses, (2) past and current medical history of nurses, (3) nurses' knowledge regarding TB, (4) practices of nurses related to TB infection control, and (5) nurses' attitude regarding TB patient. Results: The study revealed that 78% of studied nurses had satisfactory knowledge about tuberculosis and 90% of the studied nurses had satisfactory level of practices regarding prevention of TB, also 85% of the studied nurses had positive level of attitude regarding TB. Conclusion: More than three quarters of studied nurses had satisfactory knowledge and practices and positive attitude regarding TB. There was a statistically significant relation between nurses ' knowledge about TB disease and their practice. Also, there was a statistically significant relation between the positive attitude and satisfactory knowledge. Recommendation: Develop training team that works to identify training needs and put plans to increase nurse's awareness and improve their practice. For further research, investigate threats and opportunities for implementing TB-ending by 2030 program.