Background: Blood coagulation is a quick and effective process that results in the creation of clots, which demands to monitor. Many illness disorders include an abnormality in blood coagulation. This study examined the in vitro effects of methanol, ethyl acetate, and n-hexane extracts from aerial parts of Fagonia schweinfurthii Hadidi on healthy human volunteers' blood coagulation.  Methods: The Secondary metabolites were extracted from dried and crushed F. schweinfurthii aerial parts using n-hexane, ethyl acetate, and methanol, respectively. Additionally, the extracts were tested in vitro at different concentrations (10-100 µg/ml) on the blood coagulation profile, prothrombin time (PT), and activated partial thromboplastin time (a PTT) of apparently healthy human volunteers. Results: Methanol, ethyl acetate, and n-hexane extracts of F. schweinfurthii aerial parts significantly (p˃0.05) prolonged PT and PTT in the blood of healthy human volunteers with Ethyl acetate and methanol extracts recorded the largest prolongation of PT and PTT correspondingly. The highest PT and PTT prolongation was achieved at 100µg/ml, and the least prolongation time was obtained at 10µg/ml. Conclusion: These findings displayed that F. schweinfurthii aerial parts contain phytochemical constituents with anticoagulant characteristics and could be used to treat blood clotting disorders.                  Peer Review History: Received: 26 April 2022; Revised: 12 June; Accepted: 30 June, Available online: 15 July 2022 Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622,  Giza, Egypt, gehankandeel9@yahoo.com  Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com Prof. Dr. Hüsniye Kayalar, Ege University, Turkey, husniyekayalar@gmail.com Similar Articles:   GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS

Background: Antioxidant and antimicrobial properties of plant extracts are attributed to bioactive components derived from medicinal plants. This study inspected into the antimicrobial and antioxidant effects of extracts from Fagonia schweinfurthii Hadidi aerial portions. Method: Several solvents, including n-hexane, ethyl acetate, and methanol, were utilized sequentially to extract secondary metabolites from F. schweinfurthii aerial parts. Antimicrobial activity was evaluated using the well diffusion method and broth serial dilution, whilst antioxidant activity was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl radical scavenging method. Results: The findings exposed that the studied fungal strains (Candida albicans and Trichophyton rubrum) were resistant to all plant extracts. F. schweinfurthii methanol and ethyl acetate extracts demonstrated inhibitory effects on Gram-positive and Gramnegative tested bacteria with minimum inhibitory concentration between 2.5 and 20 mg/ml. In addition, the most sensitive bacterium was Proteus vulgaris, with an inhibitory concentration (2.5 and 5 mm). While the most resistant bacterium was Staphylococcus epidermidis. Due to the physical and chemical properties of the solvents, different extracts of F. schweinfurthii aerial parts exhibited diverse antioxidant capabilities in the antioxidant activity experiment. Methanol and ethyl acetate extracts exhibited IC50 values of 236 ± 0.2µg/ml and 359.4± 0.6µg/ml, respectively. Conclusion: According to the findings of this study, the aerial portions of F. schweinfurthii could be considered a possible source of natural antioxidants as well as a valuable source of antibacterial agents against bacteria that cause ear infections.