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Hendley have disclosed no financial relationships relevant to this article. This commentary does contain a discussion of an unapproved/ investigative use of a commercial product/device. Objectives After completing this article, readers should be able to: 1. Discuss the clinical presentation, diagnosis, and complications of the common cold in children. 2. Describe the viral causes and pathogenesis of the common cold. 3. Describe transmission of the common cold. Explain the systemic effects of oral decongestants and antihistamines in infants andyoung children. 5. Recognize that over-the-counter cough and cold preparations have not been adequately studied in children younger than 6 years of age and are not recommended. 6. List the active ingredients and potential toxicities of over-the-counter cough and cold medications.

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