Objective To study the expression and clinical significance of keratinocyte growth factor receptor (KGFR) and tissue factor pathway inhibitor-2 (TFPI-2) in cervical cancer tissues. Methods A retrospective analysis of 45 cervical cancer patients admitted to our hospital from January 2020 to December 2021 was used as the observation group, and 45 healthy cervical patients in our hospital during the same period were selected as the control group. The KGFR, TFPI- 2 Positive rate, pathological features and correlation with cervical cancer. result The positive rate of KGFR in the observation group was 0.00% lower than that in the control group (84.44%), and the positive rate of TFPI-2 was 100.00% higher than that in the control group ( 26.67 %) , P < 0.05. There were significant differences between KGFR positive and cervical cancer TNM stage and degree of differentiation; there were significant differences between TFPI-2 positive expression and cervical cancer TNM stage, degree of differentiation and lymph node metastasis , P <0.05. The expression level of KGFR was positively correlated with the poor prognosis of cervical cancer, and the expression level of TFPI-2 was negatively correlated with the poor prognosis of cervical cancer , P < 0.05. Conclusion The expression of KGFR is up-regulated and the expression of TFPI-2 is down-regulated in cervical cancer tissue. The expression levels of the two are directly related to the poor prognosis of cervical cancer patients , and there is a certain correlation with the incidence of cervical cancer .

Objective To investigate the relationships of leukemia inhibitory factor receptor (LIFR) with cervical cancer invasion and metastasis. Methods From January 2021 to December 2022, 45 patients treated for cervical cancer and lung metastases were identified. Western blotting was used to determine the expression of Hippo–YAP signaling pathway-related proteins. Meanwhile, 40 healthy Sprague-Dawley nude mice were used and evenly randomized into two groups, which were injected with LIFR-overexpressing (study group) or normal cervical cancer cells (control group). The lung tissue of nude mice was removed for hematoxylin–eosin staining, and the number of lung cell metastases in nude mice was counted. Results The highest LIFR mRNA expression was found in paracancerous tissue, followed by cervix cancer tissue and metastatic lesions. The study group exhibited higher LIFR, P-YAP, and P-TAZ protein expression and lower YAP and TAZ protein expression than the control group. The study group had a lower number of lung metastases than the control group. Conclusion Decreased expression of LIFR and decreased phosphorylation of Hippo–YAP signaling pathway-related proteins might be the underlying mechanisms that promote lung metastasis of cervical cancer.