Background: Colorectal cancers (CRCs) arise due to the progression of acquired or hereditary premalignant lesions. Therefore, an early diagnosis is essential to devise suitable preventive strategies against CRC. Objectives: We aimed at determining the prevalence and pattern of distribution of premalignant and malignant colorectal lesions and to assess their histopathological features. Materials and Methods: This retrospective study was conducted in the Department of Pathology at the Gujarat Cancer Society Medical College, Hospital and Research Center, a tertiary care hospital in Ahmedabad, Gujarat, India, between August 2018 and July 2020. Patients with malignant or premalignant lesions in the colorectal region who underwent biopsy and surgical resection were included, regardless of their age and sex. They were categorized as premalignant or malignant after the histopathological examination. The clinical history and details related to the age, gender, and anatomical site were obtained from the hospital records. The findings were analyzed using descriptive statistics. Results: A total of 150 colorectal biopsies and resected specimens with premalignant and malignant lesions were included in the analysis. Of these, 36 (24%) were benign and 114 (76%) were malignant. There were 98 (65.3%) male and 52 (34.7%) female patients in the cohort. There were 34.7% of the patients who were in the sixth decade of life and only 0.7% were in the first decade. The most commonly involved site was the rectum (32.7%). Ulcerative colitis (UC) (63.8%) was the most common premalignant lesion, and adenocarcinoma not otherwise specified (79.8%) was the most common malignant colorectal lesion. Conclusions: Premalignant and malignant colorectal lesions usually develop in older persons and have a male predilection, with the rectum being the most commonly involved site. UC is the most common premalignant colorectal lesion, and adenocarcinoma is the most common malignant colorectal lesion.

Background: Hepatitis C virus (HCV) is the most common cause of post transfusion non-A, non-B hepatitis worldwide. The prevalence of HCV in blood donors in high-income countries ranges from 0.002% to 0.05%, in middle-income countries ranges from 0.03% to 0.80%, and in low-income countries, prevalence varies from 0.50% to 2.23%. Objectives: The objectives of this study are to assess the seroprevalence and the trend of HCV in healthy voluntary blood donors at a tertiary care hospital in Ahmedabad over a period of 3 years. Settings and Design: Observational, retrospective study. Materials and Methods: During January 2017 to December 2019, 9477 voluntary blood donors were tested for the presence of anti-HCV antibody by using a 3rd-generation enzyme-linked immunosorbent assay test. Statistical Analysis Used: Data were statistically analyzed by using the Chi-square test, and Chi-Square test for linear trends using the Statistical Package for the Social Sciences (SPSS) software trial version 19. Results: Out of 9477 voluntary blood donors, 9229 (97.38%) donors were male and 248 (2.62%) were female. Ten donors (0.11%) were positive for anti-HCV. All seropositive donors were male. Out of total 0.11% seropositive donors, maximum (0.07%) were within the age group of 21–30 years. Seroprevalence of HCV showed a statistically significant decreasing trend over 3 years. Conclusion: Hepatitis C is a common cause of transfusion-related hepatitis. Early identification of persons with chronic HCV infection would enable infected persons to receive the necessary care and treatment to prevent or delay the onset of liver disease.