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1379taining group (i.e., the sulfonyl group), as in the change from hippurate ion to benzenesulfonylglycinate, causes a very large decrease in the strength of combination. This large effect may be entirely steric and due to the larger space requirement of two oxygens.In the absence of the carbonyl group, there seems to be some correlation between the combining power of the hapten and the distance between the benzene group and the carboxylate ion. Phenylbutyrate ion, in which the benzene and carboxylate have the same distance between them as in the homologous benzoylpropionate ion, is somewhat more effective in combining with anti-BzP antibodies than are the phenylvalerate and the phenylpropionate (hydrocinnamate) ions which contain one methylene group more or less than the butyrate.The importance of the van der Waals interaction of the benzene ring is emphasized by a comparison of the combination of anti-BzP antibody with valerate and with phenylbutyrate, AFre¡ for the combination with the aliphatic compound is at least 700 cal. greater. New York, N. Y.