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Warehouse systems are complex elements in the flow of goods and information in value-creating systems. Their efficiency and effectiveness depend to a large extent on the availability and continuity of information flow and their advanced technical and organizational resources. Recent technological developments in robotics, digitalization and Internet of Things open the pathway towards integrated and autonomous value chain operations. This book chapter describes the development of a measurement model to assess the maturity of autonomous warehouse systems beyond partially automated processes. The model considers technology readiness level, business process maturity as well as organizational capabilities. The maturity model is applied and discussed in a case study.