1In this study, a simulated lignocellulosic hydrolysate was used in a continuous two-stage fermentor set-2 up for production of acetone, butanol and ethanol. An organophilic pervaporation unit was coupled to 3 the second fermentor. The dilution rate in the first fermentor was kept constant at 0.109 h -1 while the 4 dilution rate in the second fermentor was gradually decreased from 0.056 h -1 to 0.020 h -1. Glucose was 5 completely consumed while 61% of the xylose was consumed at the lowest dilution rate, leading to an 6 overall solvent productivity of 0.65 g.L -1.h -1 and a high concentration of 185 g.kg -1 solvents in the 7 permeate in the last fermentation zone during 192h. Based on the experimental results, a process 8 integrated with organophilic pervaporation was conceptually designed and compared with a base-case. 9Chemcad simulations indicate an energy reduction of ~50% when organophilic pervaporation is used. 10This study also demonstrates significant process flow reductions and energy consumption by the use of 11 organophilic pervaporation as in situ product recovery technology. 12
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