A STUDY of orally administered attenuated poliovirus vaccine was conducted in a small community in Minnesota in 1958. In that study (1), the feeding of virus to only half of the participating families during the first half of the study provided an opportunity to study the spread of these strains of poliovirus to par¬ ticipants who received placebos. Prior to this study, intrafamily (2-4) and intrainstitutional (5) spread of attenuated poliomyelitis vaccine viruses had been reported. This study presents quantitative data on the community spread of vaccine strains of polio¬ virus. The design of the study, the vaccine strains used, the characteristics of the study population, the illnesses observed during the study, and the method of surveillance used to detect such illnesses were described in the earlier report (1).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.