SummaryA capillary zone electrophoresis method has been developed and validated for the analysis of chlortetracycline and related substances. The influence of the type of buffer, pH and concentration of the buffer were investigated. In all cases 1 mM EDTA was added to prevent metal ion eomplexation. Instrumental parameters such as capillary temperature and applied voltage were optimised. The following method is proposed: capillary: fused silica, 44 cm (36 cm effective length), 50 pm i. d.; buffer: 120 mM sodium tetraborate including 1raM EDTA at pH 8.5; voltage: 10 kV; temperature: 25 ~ detection wavelength: 280 nm. The robustness of the method has been examined by means of a full-fraction factorial design. The parameters for validation namely relative standard deviation, linearity, precision, limit of detection and limit of quantitation are also reported.

The ability to change the physical location of objects is considered indispensable in today's highly distributed computing world. As a direct ogspring of process migration, object-oriented operating systems now offer object migration as a core mechanism. These systems usually equate migration with a change in physical location.Location is only one attribute whose changes are worth considering. Other attributes evolve as well during the lifetime of an object. Examples include changes in state representation and failure handling semantics. All such attribute changes can be integrated within a generalized object migration model. This results in an Ndimensional space, the object habitat, where object migration is expressed in terms of coordinate changes.This paper introduces the habitat model, and illustrates its application within the COMET heterogeneous distributed computing system. Within COMET, the habitat is a three-dimensional space with location, class and flavor coordinate axes.

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