Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Noni fruit proved to have antihypertensive effect. Noni Fruit contains scopoletin and xeronin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of noni fruit extract to controlling hypertension. The research method used is pre-test and post-test matched control group. The 6 Wistar rats were divided into 3 groups consisting of 1 treatment group and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml noni fruit extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg. The results showed that epinephrine can be used as a hypertensive inducer. Noni fruit extract as much as 6ml can provide antihypertensive effects. In Vitro, test result showed that noni fruit extract can reduce blood pressure by an average decrease in blood pressure of 58,5 mmHg While captopril 25,5 mmHg. in addition to the in vitro test, the results of the in-silico test showed that the noni fruit extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of scopoletin in noni fruit is -7.6. and captopril only -5.7.

Foot alignment merupakan keselarasan sumbu vertikal tubuh terhadap posisi normal kaki yang dapat mempengaruhi keselarasan mekanis dan fungsi dinamis ekstremitas inferior yang dapat memberikan dukungan dan menjaga keseimbangan tubuh. Malalignment pada struktur kaki menunjukkan adanya gangguan biomekanik, seperti overpronation memungkinkan terjadi perubahan struktur dan fungsional tubuh yang dapat mempengaruhi ekstremitas inferior dan ekstremitas superior. Penelitian ini bertujuan untuk mengetahui pengaruh Eccentric Strengthening Exercises terhadap perubahan Foot Alignment, Malleolus Height dan Tingkat Agility. Penelitian ini merupakan penelitian quasi-experimental design dengan rancangan penelitian time-series experimental design. Populasi penelitian adalah pemain bulu tangkis junior di Kota Makassar usia 11-15 tahun. Pengambilan sampel menggunakan teknik purposive sampling dengan jumlah sampel 32 orang. Pengumpulan data dilakukan melalui pengambilan data primer melalui instrumen pengukuran foot alignment , malleolus height dan agility. Data yang terkumpul dilakukan uji normalitas menggunakan Shapiro Wilk Test. Sebaran data berdistribusi normal. Kemudian dilakukan uji perbedaan pre test dan post test menggunakan uji repeated anova untuk data berdistribusi normal dan uji friedman untuk data berdistribusi tidak normal. Dari hasil pengukuran diperoleh nilai signifikan p=0,0001 (p<0,05) setelah 18 kali pemberian latihan. Penelitian menunjukkan bahwa adanya pengaruh eccentric strengthening exercise terhadap perubahan foot alignment, malleolus height dan tingkat agility pada pemain bulu tangkis junior di kota makassar.

Introduction: Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Cucumber proved to have antihypertensive effect. cucumber contains ficetin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of cucumber extract to controlling hypertension. Methods: The research method used is pre-test and post-test matched control group. The 6 wistar rats were divided into 3 groups consisting of 1 treatment groups and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml cucumber extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg Results The results showed that epinephrine can be used as a hypertensive inducer. cucumber extract as much as 6ml can provide antihypertensive effects. In Vitro test result showed that cucumber extract can reduce blood preassure by an average decrease in blood preassure of 102 mmHg While captopril 25,5 mmHg. Conclusions: in addition to the in vitro test, the results of the in silico test showed that the cucumber extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of fisetin in cucumber is -9.3. and captopril only -5.7.Keywords: Hypertension, cucumber extract, In Silico, In Vitro