Today, malaria prevention hinges upon two domestic interventions: insecticidetreated bed nets and indoor residual spraying. As mosquitoes grow resistant to these tools, however, novel approaches to vector control have become a priority area of malaria research and development. Spatial repellency, a volumetric mode of action that seeks to reduce disease transmission by creating an atmosphere inimical to mosquitoes, represents one way forward. Drawing from research that sought to develop new repellent chemicals in conversation with users from subSaharan Africa and the United States, we consider the implications of a noninsecticidal paradigm of vector control for how we understand the political ecology of malaria.

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