Background: Lymph nodes cancer is one of chronic diseases that require long-term care. Family caregivers as the closest one who lives with the cancer patient takes a significant role in providing care. This causes an important burden on caregivers and decreases their quality of life. Objective: The aim of the current study is to assess the quality of life for family caregivers of patients with lymph nodes cancer. Subjects and methods: A descriptive study was conducted in outpatient Cancer Clinic of General Fayoum Hospitals. Purposive sample was used and included 240 family caregivers. Tools of the study included: (1): Interviewing Questionnaire sheet that included two parts, Part I: Demographic characteristics, Part II: Knowledge Assessment Sheet, (2): Caregiver Quality of Life Index. Result: Up to 80% of the sample under investigation knew too little overall about lymph node cancer. There were statistically significant associations between the total knowledge scores of family caregiver of lymph node cancer patients and their age, educational attainment, and monthly income, as well as statistically significant associations between some socio-demographic data and their quality of life. Additionally, there was a highly statistically significant positive correlation between the total knowledge scores and the total quality of life. Conclusion: Majority of family caregivers with cancer patients had poor quality of life and unsatisfactory knowledge. Implementation of educational programe for family caregivers with cancer patients to enhance their quality of life is needed.