Heat shock proteins (HSPs) encompass both extrinsic chaperones and stress proteins. These proteins, with molecular weights ranging from 14 to 120 kDa, are conserved across all living organisms and are expressed in response to stress. The upregulation of specific genes triggers the synthesis of HSPs, facilitated by the interaction between heat shock factors and gene promoter regions. Notably, HSPs function as chaperones or helper molecules in various cellular processes involving lipids and proteins, and their upregulation is not limited to heat-induced stress but also occurs in response to anoxia, acidosis, hypoxia, toxins, ischemia, protein breakdown, and microbial infection. HSPs play a vital role in regulating protein synthesis in cells. They assist in the folding and assembly of other cellular proteins, primarily through HSP families such as HSP70 and HSP90. Additionally, the process of the folding, translocation, and aggregation of proteins is governed by the dynamic partitioning facilitated by HSPs throughout the cell. Beyond their involvement in protein metabolism, HSPs also exert a significant influence on apoptosis, the immune system, and various characteristics of inflammation. The immunity of aquatic organisms, including shrimp, fish, and shellfish, relies heavily on the development of inflammation, as well as non-specific and specific immune responses to viral and bacterial infections. Recent advancements in aquatic research have demonstrated that the HSP levels in populations of fish, shrimp, and shellfish can be increased through non-traumatic means such as water or oral administration of HSP stimulants, exogenous HSPs, and heat induction. These methods have proven useful in reducing physical stress and trauma, while also facilitating sustainable husbandry practices such as vaccination and transportation, thereby offering health benefits. Hence, the present review discusses the importance of HSPs in different tissues in aquatic organisms (fish, shrimp), and their expression levels during pathogen invasion; this gives new insights into the significance of HSPs in invertebrates.

Recently the shrimp farming has blooming as a crucial counterpart in the aquaculture industry which contribute the remarkable role in sea food production as well economy of the country. However, this could be fluctuated every year through several circumstances such as unfavorable (Poor water and soil quality) environmental factors. The environmental factors includes disease causing bacterial pathogens in the soil and water which causes the bacterial diseases in the aquatic animals, like this hectic problems are prevented through bioaugmentation strategies. The pond environment plays a vital role in determining the healthy culture system, but there is high risk for manipulation by bacterial community which takes care of waste generated in the system through in situ bioremediation. Due to the impact of rapidly growing bacterial diseases of shrimps throughout the world, numerous studies have been carried out to find immunostimulants, immunomodulators and biotic component that can be used against vibrio causing pathogens, and can also be used as an alternative for antibiotics. Recent research focus towards the marine resources such as microalgae, seaweed, live feeds (like artemia, copepods, rotifers), bacteriophage, and probiotics have been found to have higher potential in reducing vibriosis. Eco-based shrimp farming includes green water technology, phage therapy bio-floc technology (BFT) and integrated multi-trophic aquaculture (IMTA), these methods hold a promising alternative to antibiotics in the near future. Bacterial diseases caused by vibrios have been reported in penaeid shrimp culture systems implicating at least 14 species and they are Vibrio harveyi, V. splendidus, V. parahaemolyticus, V. alginolyticus, V. anguillarum, V. vulnificuslogei etc.

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