BackgroundPeriodontitis is a major oral health problem and it is considered as one of the reasons for tooth loss in developing and developed nations. The objective of the current review was to investigate the association between IL10 polymorphisms − 1082 A > G (rs1800896), -819C > T (rs1800871), − 592 A > C (rs1800872) and the risk of either chronic periodontitis or aggressive periodontitis.MethodsThis is a meta- analysis study, following the preferred reporting items for systematic reviews and meta- analyses (PRISMA). Relevant studies were searched in the health related electronic databases. Methodological quality of the included studies were assessed using the Newcastle-Ottawa Scale. For individual studies, odds ratio (OR) and its 95%confidence interval (CI) were calculated to assess the strength of association between IL10 polymorphisms (− 1082 A > G, -819C > T, − 592 A > C) and the risk of periodontitis. For pooling of the estimates across studies included, the summary OR and its 95% CIs were calculated with random-effects model. The pooled estimates were done under four genetic models such as the allelic contrast model, the recessive model, the dominant model and the additive model. Trial sequential analysis (TSA) was done for estimation of the required information size for this meta-analysis study.ResultsSixteen studies were identified for this review. The included studies were assessed to be of moderate to good methodological quality. A significant association between polymorphism of IL10–1082 A > G polymorphism and the risk of chronic periodontitis in the non-Asian populations was observed only in the recessive model (OR,1.42; 95% CI:1.11, 1.8,I2: 43%). The significant associations between − 592 A > C polymorphism and the risk of aggressive periodontitis in the non-Asian populations were observed in particular genetic models such as allele contrast (OR, 4.34; 95%CI:1.87,10.07,I2: 65%) and recessive models (OR, 2.1; 95% CI:1.16, 3.82,I2: 0%). The TSA plot revealed that the required information size for evidence of effect was sufficient to draw a conclusion.ConclusionsThis meta-analysis suggested that the IL10–1082 A > G polymorphism was associated with chronic periodontitis CP risk in non-Asians. Thus, in order to further establish the associations between IL10 (− 819 C > T, − 592 A > C) in Asian populations, future studies should include larger sample sizes with multi-ethnic groups.Electronic supplementary materialThe online version of this article (10.1186/s12903-018-0637-9) contains supplementary material, which is available to authorized users.

Aims: To identify follow-up rate and evaluate the endodontic outcome and their association with technical quality of root canal therapy (RCT) done by dental undergraduates.Method: Technical quality of RCT and follow-up rate visits of 350 teeth from 272 patients after RCT done by dental undergraduates were evaluated retrospectively from year 2012 to 2015 using the electronic records. These patients were recalled to assess the clinical, radiographic and overall endodontic outcome. Clinical and radiographic examinations were done following the criteria in compliance with standards guidelines. Each RCT was considered successful when clinical and radiographical findings were satisfactory. Association between technical quality of RCT and endodontic outcome was analysed using chi-square test. Results:The retrospective electronic records revealed only 16% of follow-up rate and 59 (21.7%) patients attended the recall visits and 90 teeth (25.7%) of these patients were assessed. The clinical, radiographic, endodontic success, and acceptable technical quality of RCT were observed in 72.2%, 85.6%, 60.7%, and 51.1% respectively. There was no significant association observed in between technical quality of RCT and endodontic outcome (p=0.10). Conclusions:The follow-up rate visits done by dental undergraduates after completion of RCT was low. The success rate of RCT performed by dental undergraduates was 66.7% with no significant association in between the technical quality of RCT and endodontic outcome.