This study aims to establish a mathematical model for the Continuous Stirred Tank Reactor (CSTR) reactor that exhibits highly nonlinear dynamics and was carried out implemented by model-based conventional and non-conventional controllers for temperature control. The developed controllers were Proportional, Proportional-Integral, Proportional-Derivative, Proportional-Integral-Derivative, Two Degrees of Freedom, and Model Predictive Controller. Then, the controllers were simulated, tuning, and optimized using Matlab®/Simulink®. The response results were compared and the analysis performed. The results indicated that the performance of 2-DOF-PID and MPC controllers is better than other conventional controllers for nonlinear systems such as the CSTR process. Bangladesh J. Sci. Ind. Res. 57(3), 149-162, 2022

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