The aim of this project was to develop and validate a new test for the analysis of glucocorticoids in camel hair and to use the new test to analyse hair samples from a variety of camel breeds in sports and racing applications. These findings could be of importance when evaluating racing camels for suspected doping offenses or for injury and disease control. Camel hair samples were collected from 30 non-racing dromedary camels along with 3 racing camels in Al Ain, UAE and were decontaminated, pulverised, sonicated, and extracted prior to analysis. A liquid chromatographic-mass spectrometric method was employed to determine the levels of glucocorticoids in the hair samples. The 4 drugs of interest, namely hydrocortisone, dexamethasone, flumethasone and methylprednisolone, and an internal standard were quantified in camel hair samples. All 4 of the glucocorticoids were detected in camel hair samples with concentrations ranging between 31 and 935 pg/mg for hydrocortisone, 8-59 pg/mg for dexamethasone, 0.7-1034 pg/mg for flumethasone and 5-66 pg/mg for methylprednisolone in non-racing camels. One of the racing camels displayed high concentrations of hydrocortisone (1130 pg/mg), flumethasone (2576 pg/mg), methylprednisone (1156 pg/mg) and dexamethasone (29 pg/mg). The authors believe this is the first report of a test for corticosteroids in camel hair. The new test has been validated according to Food and Drug Administration (FDA) guidelines. This new hair test could be useful for further studies in doping control, toxicological studies, pharmacological studies and other clinical applications in camel health, injury, and disease.

<p><strong>Objective<em>:</em></strong> To determine the prevalence of malocclusion and orthodontic treatment needs in Sudanese’s Down syndrome individuals in Khartoum area. <strong>Material and Methods: </strong>A total of 75 (37 males and 38 females) Down syndrome individuals age ranging from 6-28 years of age, were clinically examined after obtaining their guardian’s consent. Malocclusion was determined based on Angle and Incisor classification of malocclusion. The data were analysed and presented in tables using the Statistic Package for social sciences (SPSS) program version17 descriptive statistic, Frequency distribution tables and graph were utilized to perform the results. <strong>Results: </strong>Angle Class III malocclusion (58.7%) and Incisor III malocclusion<strong> </strong>(53.3%) represents the most prevalent types of malocclusions. Angle class III malocclusion was more frequent among females (60.5%) than males (56.8%).The majority of individuals with Down syndrome are in great need for orthodontic treatment (85.3%). <strong>Conclusion: </strong>The prevalence of malocclusion and orthodontic treatment need among Sudanese Down syndrome individuals was high.  Angle and Incisor class III malocclusions represent the commonest trait of malocclusion and reported more frequency in females than males.<strong> </strong>Orthodontic treatment for Down syndrome individual should be multidisciplinary in order to conservative superior treatment pattern.</p><p> </p><p><strong>Keywords:</strong> Down syndrome; Class III malocclusion; Orthodontic treatment.</p>

Objective: To determine prevalence of malocclusion and orthodontic treatment needs in Down syndrome individuals among Sudanese population in Khartoum area.Materials & Method: A total of 75 (37 males and 38 females) Down syndrome individuals age ranging from 6-28 years were clinically examined after obtaining their guardian’s consent, malocclusion was determined based on Angle and Incisor classification. Exclusion criteria were included individuals who had history of extraction and orthodontic treatment.Data was analysed by using SPSS Version 17, at an alpha level 0.05 and 95% confidence limits.Result: Angle Class III and Incisor III malocclusion represents the most prevalent type of malocclusions (58.7%) Angle classification, (53.3%) Incisors classification. Angle Class III malocclusion was more frequent among females (60.5%) than in males (56.8%). Themajority of individuals with Down syndrome are in need of orthodontic treatment (85.3%).Conclusion: The prevalence of malocclusion and orthodontic treatment need among Sudanese Down syndrome individuals was high. Angle and Incisor Class III malocclusion representing commonest trait of malocclusion with more frequency in femalesthan males.Key word: down syndrome, Class III malocclusion, orthodontic treatment