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Introduction: A potentially malignant oral lesion (PMOL) refers to a morphologically altered tissue that has a higher likelihood of developing cancer compared to its apparently normal counterpart. Among PMOLs, leukoplakia is the most common lesion found in the oral mucosa. The aim of study is to evaluate clinical characteristics of oral lesions by comparing with histopathological diagnosis. Method: included a descriptive analysis of data from 75 patients seen between May 2022 and May 2023 at the oral and maxillofacial surgery clinic at AL-Yarmouk Teaching Hospital, Ghazi AL-Hariri Hospital for specialized Surgery. Information about the patient's age, the lesion's location and duration, the clinician's diagnosis, and the ultimate histological diagnosis and course of therapy. Each patient's medical history was taken after a thorough examination of their mouth. Results: 81.8% of oral surgeon-diagnosed malignant lesions are also hitopathologist-diagnosed. The hitopathologist confirms 97.8% of oral surgeon-diagnosed benign lesions. Conclusion: Clinical evaluation and histological diagnosis were significantly correlated, indicating that Iraqi maxillofacial surgeons were well-trained and that clinical diagnosis of mouth cancer was highly correlated with pathological diagnosis.