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Neglected diseases are a group of communicable diseases that mainly affect tropical regions in developing countries. Among this group of diseases is Chagas disease, which has been classified among the six most important parasitic diseases in the world, and it is estimated that more than one billion people are at risk in countries that are considered endemic. The aim of this study is to conduct a literature review on the trypanocidal activity of thiosemicarbazone derivatives. The study is a review research that used 31 articles to highlight the scientific findings on the trypanocidal activity of the derivatives in question. Articles were included in the time estimate between 2010 - 2021 (last 12 years). The search and selection of the reference studies was performed in Scielo, Science Direct, PubMed and Google Academic databases. The literature highlights that thiosemicarbazones are considered privileged compounds with a wide scientific interest due to their diverse chemical and biological properties, such as: antitumor, antibacterial, antiviral, antiprotozoal, and anti-chagasic. The studies presented here, which demonstrate the investigations of compounds of this class and their derivatives, are an important step towards the conception of therapeutic methods against Trypanosoma cruzi. New studies are necessary to elucidate in an even more specific way the effects of these derivatives in vivo, in order to obtain an alternative pharmacological therapy for Chagas disease.

Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the genus Leishmania and characterized by the formation of skin ulcers. Despite the large number of cases, reaching worldwide proportions, there are many factors to be discussed regarding the treatment of the disease, which although much discussed, is still poorly elucidated. The objective of this review study is to identify the main anti-Leishmania mechanisms of Annona glabra L. (Annonaceae). This is a literature review study. To this end, we used the following descriptors in the search: natural products, leishmaniasis, mechanism of action and Leishmania (together and separately). In the selection criteria we opted for full articles, in the period 2012 - 2021 (last 10 years), in Portuguese and English. The searches were performed in the following databases: Scientific Electronic Library Online (SciELO), Latin American and Caribbean Literature on Health Sciences (LILACS) and Google Scholar. The articles were selected first by title, then by abstract, and finally by complete reading. The potential of natural products and their use in traditional medicine for the treatment of diseases makes them the target of research for new drugs. Different Annona species have demonstrated antileishmanial activity when evaluated in vitro. The substances that show leishmanicidal activity in Annona glabra extract are the alkaloids. New studies can be developed to elucidate even more specifically the effects of this natural product in vivo, in an attempt to obtain a new pharmacological alternative for the treatment of leishmaniasis.