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SUMMARYAn attempt was made to derive a useful noninvasive index to evalute a change in myocardial contractile state using transcutaneous Doppler flow-velocity curve from the carotid artery.In 5 mongrel dogs and in 43 patients with various heart disease, Doppler flow velocity curves were obtained from the ascending aorta intravascularly using a Doppler catheter and/or from carotid artery transcutaneously using a Doppler probe. The first derivative of left ventricular pressure (dp/dt) and electrocardiogram (ECG) were recorded simultaneously. The following 3 indices were measured from the Doppler flowvelocity curves: (1) maximum acceleration of blood flow (dv/dt), (2) time from onset of ejection to peak flow (time-to-peak), (3) time interval between the beginning of Q wave of ECG to the peak of Doppler flow velocity curve (ECG Q-Doppler peak). Among these 3 indices, only ECG QDoppler peak demonstrated a significant correlation between the values measured intravascularly and transcutaneously. Also, only ECG QDoppler peak showed significant correlation with maximum of dp/dt (max dp/dt). Since ECG Q-Doppler peak showed correlation with heart rate, the difference between observed and predicted ECG Q-Doppler peak (zJECG Q-Doppler peak) was calculated to exclude the effect of heart rate. Predicted value of ECG Q -Doppler peak was calculated from the regression equation between heart rate and ECG Q: Doppler peak in the separate experiments. There was a significant correlation between 4ECG QDoppler peak and max dp/dt.In 15 patients with coronary artery disease and in 16 healthy subjects, 1ECG Q-Doppler peak and the other noninvasive method (systolic time intervals) were measured. JECG Q -Doppler peak showed better result in the separation of 2 groups than by systolic time intervals. It

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