No abstract

Multicentric gliomas are among the rarest of multiple intracranial neoplasms. Two biopsy proven cases are described with a review of the literature. Both cases had supratentorial and posterior fossa lesions. Computed tomography was performed in both cases, open and stereotaxic biopsy was done in one case and open biopsy of both lesions in the other case. The major problem in multicentric gliomas is the management. The two cases were managed differently based on the clinical condition and the location of the lesions.

We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation in predicting the domperidone (DOM) triggered pseudo-electrocardiogram modification in the presence of a CYP3A inhibitor, ketoconazole (KETO), using in vitro–in vivo extrapolation. In vitro metabolic and inhibitory data were incorporated into physiologically based pharmacokinetic (PBPK) models within Simcyp to simulate time course of plasma DOM and KETO concentrations when administered alone or in combination with KETO (DOM+KETO). Simulated DOM concentrations in plasma were used to predict changes in gender-specific QTcF (Fridericia correction) intervals within the Cardiac Safety Simulator platform taking into consideration DOM, KETO, and DOM+KETO triggered inhibition of multiple ionic currents in population. Combination of in vitro–in vivo extrapolation, PBPK, and systems pharmacology of electric currents in the heart was able to predict the direction and magnitude of PK and PD changes under coadministration of the two drugs although some disparities were detected.

We report two cases of primary Ewing's sarcoma of the skull. The literature contains previous reports of only four such cases.

Two cases of primary tuberculous osteomyelitis of skull confirmed by appropriate laboratory investigations are described here. Primary tuberculous osteomyelitis of skull is rare. Only two cases of chronic granulomatous osteomyelitis have been described so far in the literature.