The hybrid congeners 62-90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats and db/db mice. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared, and their antidiabetic activity results indicate its association mainly with S isomers. These compounds also lower cholesterol and TG profiles while improving high-density lipoprotein cholesterol to CHOL ratio in db/db mice. The bioavailability of compound 70 and its isomer varies between 27 and 29% whereas that of the more polar compound 90a is poor as determined in rat by oral and intraperitoneal administrations.

The present research makes use of a braiding-cum-weaving technique for the fabrication and investigation of electricity-induced heating fabrics. Braided conductive yarns (BCYs) were produced using a Maypole braiding machine by introducing conductive copper filament as the core and polyester multifilament yarn as the sheath. A different number of polyester yarns, 6-, 10-and 16-end, were used to cover the copper core. Electrically heating fabrics (e-HFs) were fabricated by interweaving the BCYs through pick insertion in a plain-woven construction at 4-, 8-and 12-pick spacing. Various electro-mechanical tests were carried out on the BCYs and e-HFs. The mechanical performance of 16-end BCY was the most superior while 6-end BCY exhibited the poorest performance amongst the three BCY-types. The temperature profiles obtained via thermal mapping elucidate the difference in the heat-barrier effect of each of the BCYs. It also shows the presence of overlapping concentric (cylindrical) isotherms running along the axes of the BCYs. These isotherms have shown to significantly affect the temperature uniformity on the e-HF surface. Heating response under different variables-pick-spacing, time, voltage and input power, were evaluated, and direct correlations were found. A temperature of about 89.8 °C was attained at 5 V after 40 min of heating. For an input power of 3, 5 and 7 W, a maximum temperature of 40.5, 48.8 and 55.3 °C was measured for different e-HFs. Wash and sweat durability tests were also carried out to corroborate the utility of the e-HFs for day-today usage. These tests proved to have a minimal detrimental effect on the heating performance of the e-HFs establishing a good utilitarian quotient of such material for the purpose of wearable electronics and essentially, as active heating garments.

A number of 5-chloro-3'-nitro-4'-substituted salicylanilides (6--23) have been synthesized by treating 4',5-dichloro-3'-nitrosalicylanilide (5) with various sodium aryl oxides, alkoxides, or amines. These compounds have been tested against Hymenolepis nana infection in rats and have also been evaluated for their in vitro antimicrobial activity against various strains of bacteria and fungi. In the former test 17 was the most active cestodicidal agent showing activity at 30 mg/kg. In the antimicrobial screening, 22 inhibited the growth of all the bacteria and fungi used while 6 was active against the penicillin resistant Staphylococcus aureus at a minimum inhibitory concentration of 0.00609 microgram/mL.

A series of novel mannich bases of 2-substituted benzimidazoles was synthesized by the reaction of 2-substituted benzimidazoles with corresponding aldehyde and acetophenones. The structures of all synthesized compounds were confirmed by elemental analysis, IR, 1 H-NMR, 13 C-NMR and LCMS. The compounds were evaluated for in vivo analgesic and in vivo anti-inflammatory activities by a tail flick method and carrageenan-induced rat paw edema test respectively. Among all the compounds synthesized, compound A1 and B3 exhibited significant analgesic and anti-inflammatory activities. Acute ulcerogenicity studies showed that compound A1 and B3 were devoid of gastrointestinal toxicities.

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