Background: Serum amylase has a short biological half-life and returns to normal levels within short time. Thus it’s quite conflicting in the diagnosis of acute pancreatitis, particularly in patients with mild acute pancreatitis. Therefore, present study investigates the urinary amylase levels in the diagnosis of acute pancreatitis.Methods: The present prospective study was conducted on 100 patients, 50 with acute pancreatitis and 50 normal subjects in the departments of General Surgery and our surgical hospital. All patients were examined by clinically, biochemical and radiological investigations and diagnosed acute pancreatitis. Serum amylase levels, serum lipase levels and urinary amylase levels were estimated in both groups: cases and controls. The sensitivity and specificity of serum amylase, serum lipase and urinary amylase levels were established after comparing their values in cases and controls.Results: The preponderance of the patients was aged between 21 and 50 years. Increase the serum amylase, lipase and urinary amylase mean values of patients with acute pancreatitis were observed statistically significant (p<0.001). Serum amylase had the highest sensitivity (100%) and serum lipase had the highest specificity (96.53%). The sensitivity and specificity of urinary amylase was found to be 97.25% and 91.47% respectively. On ROC curve analysis, the area under the curve for serum amylase, serum lipase and urinary amylase was found to be 0.845, 0.945 and 0.934.Conclusions: We conclude that urinary amylase is a convenient and a more sensitive test for diagnosis of acute pancreatitis.

Background: The diagnostic like history, clinical examination and prejudiced role of white cell count and C-reactive protein (CRP) in acute appendicitis has been studied widely but still remains controversial. Therefore, the purpose of this study was to evaluate the diagnostic value of CRP, Total leucocytes count, bilirubin levels individually in cases of acute appendicitis and its complications. Methods: This randomized prospective study was conducted in department of Surgery and our surgical hospital, Palanpur Gujarat. Total included 50 cases of clinically and radiologically diagnosed of acute appendicitis. The diagnostic value of these markers was predicted for the all groups in terms of sensitivity, specificity, PPVs and NPVs using sensitivity analysis and the diagnostic accuracy assessed. Results: Acute appendicitis is the most common in female predominance with age group of 20-29 years and <20 years. The Inflamed appendix was diagnosed in 35 (70%) patients, Gangrenous appendix in 5 (10%) patients and Perforated appendix 4 (8%) patients. Patients with Perforated appendicitis had higher total bilirubin, TLC and CRP levels as compared to patients with normal and inflamed appendix (p<0.001) or a normal appendix (p<0.001). The CRP has highest sensitivity and specificity (74%, 52%) followed by bilirubin (65%, 70%), WBC count (60.2%, 89.5%). Conclusions: TLC, CPR and bilirubin can be helpful in the diagnosis and decision-making of patients with suspected acute appendicitis.