SUMMARYBackground: Eradication of Helicobacter pylori is expected to prevent the development of gastric cancer. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. Aim: To conduct a prospective study to determine the clinical features of patients who underwent successful eradication and were later diagnosed with gastric cancer. Methods: A total of 1787 patients (1299 males and 488 females; mean age, 58.2 years; range: 15-84) who underwent successful eradication therapy between April 1994 and March 2001 were our study subjects.

Acotiamide significantly enhances GAR and GER in FD patients. Acotiamide may have therapeutic potential for FD patients.

INTRODUCTIONRecent studies have shown that the eradication of Helicobacter pylori leads to normalized gastric acid secretion 1±3 and prevents ulcer recurrence in patients with peptic ulcer diseases. 4,5 Now, the focus is on whether the eradication of H. pylori reverses the decrease in gastric acid secretion seen in patients with chronic gastritis, because hypo-or achlorhydria is known to be an important risk factor for the development of gastric cancer.6±8 Several recent studies have shown an increase in gastric acid secretion in H. pyloripositive subjects after H. pylori eradication therapy, 9±13although the mechanism responsible for this change remains unclear.In this study we evaluated the effect of H. pylori eradication on 24-h acidity in patients with moderate or severe atrophic gastritis of the corpus. In addition, we investigated whether atrophy was reversible after the eradication of H. pylori. SUBJECTS AND METHODS SubjectsSixteen H. pylori-positive patients with histologically proven moderate or severe atrophic gastritis of the corpus were enrolled in a pre-and post-therapy design SUMMARY Background: Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. Aim: To evaluate the effect of eradication of H. pylori in a 24-h study of gastric acidity in patients with atrophic gastritis of the corpus. Methods: Intragastric acidity was measured by continuous 24-h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pyloripositive patients with histologically proven atrophic gastritis of the corpus (10 men, four women; mean age, 57 years) before and 1 year after anti-H. pylori therapy.

There has been a progressive and rapid decline in the prevalence of H. pylori infection as well a fall in the rate of progression of gastric atrophy among H. pylori-infected Japanese coincident with the westernization and improvements in economic and hygienic conditions in Japan since World War II.

In functional dyspepsia patients, delayed gastric emptying of a solid meal was related to antral hypomotility during the early postprandial phase. Ultrasonographic assessment of gastric motility in both liquid and solid meals may provide a better understanding of the pathogenesis of functional dyspepsia.