SynopsisGels of syndiotacticity-rich poly(viny1 alcohol) (s-PVA) in mixed solvents of water/dimethyl sulfoxide (DMSO) or water/ethylene glycol (EG) were made by chilling at the temperatures of 0-70 O C from those solutions with the polymer concentrations below 10 g/dL. The melting points of the gels were measured warming the gel from the gelling temperature (Tge,) at a constant heating rate. The apparent enthalpy of fusion of a junction of gel, AH was estimated from the relation between the apparent melting temperature and the polymer concentration. The s-PVA gels made from the mixtures of the water/lower contents of DMSO or EG had a minimum at lower Tgel and a maximum AH at a higher Tgel. On the other hand, the s-PVA gels made from the mixtures of the water/higher contents of them had nearly a maximum AH at a higher Tge,. From those results, it was considered that the former gels received a high thermal history while the latter gels received only slight thermal history.

The chemokines are members of a bipartite superfamily of soluble proteins that have been implicated in a wide range of acute and chronic inflammatory processes, as well as other immunoregulatory functions. Macrophage inflammatory protein-1 alpha (MIP-1alpha) belongs to the C-C subfamily of these chemokines and is primarily a potent chemoattractant and activator of monocytes. MIP-1alpha is also thought to play a role in host defence. We examined the expression of MIP-1-alpha in normal lung, inflammatory lung tissue and lung cancer cells by the immunoperoxidase method using a MIP-1alpha monoclonal antibody. MIP-1alpha protein was found to be expressed not only by alveolar macrophages, but also by bronchial ciliated cells, hyperplastic alveolar type II cells and activated fibroblasts surrounding malignant tissue. Of 33 cases of lung cancer, 23 (70%) expressed MIP-1alpha. These observations suggest that lung cancer cells, non-neoplastic alveolar type II cells and fibroblasts can participate in inflammatory cell recruitment via the production of MIP-1alpha. Tumour derived MIP-alpha may also affect the interaction between lung cancer and host inflammatory cells.

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The cystadenomas were of two types: 1 Tumours with small loculi lined by cubical epithelium, in which there was little secretion of mucus by the epithelium but abundant mucoid stroma. There were six of these tumours and we have no evidence of malignant change in this type. 2 Tumours with relatively large cystic spaces filled with mucus and lined by tall, mucus-secreting epithelium. There were eight of these, and the possibility of malignant transformation in this type of tumour is indicated by the finding that in three cases of cystadenocarcinoma two appeared to have been preceded by simple mucus-secreting cystadenomas.Signs of recent or old haemorrhage were common in both types of cystadenoma and also in the cystadenocarcinomas.