No abstract

P r e p a r a t i o n o f a 2 ¢ -O -A c e t y l -1 ¢ -O -( 4 -m e t h o x y b e n z y l ) -L -b i o p t e r i n D e r i v a t i v e Abstract: L-Rhamnose was converted, over a 13-step-sequence, into 2¢-O-acetyl-N 2 -(N,N-dimethylaminomethylene)-1¢-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]-L-biopterin, an appropriately protected precursor of 1¢-O-and 2¢-O-monoglycosyl-L-biopterin.Thus, the first selective synthesis of these L-biopterin glycosides was accomplished by treatment of the precursor with either DDQ or sodium methoxide, then with tetra-O-benzoyl-a-D-glucopyranosyl bromide in the presence of silver triflate and tetramethylurea, followed by removal of the remaining protecting groups.

the presence of silver triflate and tetramethylurea, followed by successive removal of the protecting groups.