No abstract

Total synthesis of Hirsutellone B has been achieved by a convergent synthetic strategy. This synthesis features direct construction of the highly strained 13-membered macrocycle of Hirsutellone B utilizing the Ullmann-type reaction. To the best of our knowledge, this is the first application of macrocyclization utilizing an intramolecular Ullmann-type reaction between an aliphatic alcohol and aryl halide.

No abstract

Anti-α,β-dihydroxy thioesters are prepared with excellent enantioselectivities by the asymmetric aldol reaction between both achiral aldehydes and silyl enol ethers derived from α-benzyloxy thioesters in the presence of a chiral promoter consisted of chiral diamine coordinated tin(II) triflate and dibutyltindiacetate.

Highly enantioselective aldol reaction of silyl enol ethers with aldehydes is performed by the use of a catalytic amount of chiral diamine coordinated tin(II) triflate according to a slow addition procedure.