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Acute hypotension was produced in rats by using two experimental techniques: intravenous infusion of a ganglion-blocking agent (Arfonad), and venesection of a femoral vein. Horseradish peroxidase (HRP) was injected intravenously after each procedure, and subsequently observed in the inner ear by light and electron microscopy. In both experimental models, a large amount of tracer spread into the intercellular spaces, but it was halted by tight junctions bordering the stria vascularis. The endothelium exhibited a high distribution density of labelled vesicles, which suggested increased vesicular transport. There was no extravasation of HRP from capillaries in the spiral ligament in spite of the presence of some labelled pinocytotic vesicles. The present study was concerned with the discovery of enhanced capillary permeability of the stria vascularis under acute hypotension, as in the case of acute hypertension (Sakagami et al., 1984).

A 43-year-old housewife, who had complained of retrosternal obstruction, vomiting and anorexia of several years' duration, was diagnosed as having Plummer-Vinson (Paterson-Brown Kelly) syndrome complicated by esophageal candidiasis.2) Clinically, esophageal candidiasis is not so frequent as is found in autopsy.Esophagoscopy is necessary for the detection of esophageal candidiasis , since the disease is easily overlooked by fluoroscopy.In this respect , practical use of a fiber scope as an esophagoscopy is urgent.3) Esophageal findings of Plummer-Vinson (Paterson-Brown Kelly) syndrome were reviewed on the reported cases and the relation of the disease to esophageal candidiasis was discussed