SUMMARY:The association between Helicobacter pylori infection and tooth loss has been studied in Western countries; however, this relationship remains controversial. Although the prevalence of H. pylori infection is higher and atrophic gastritis is usually observed in patients with H. pylori infection in Japan unlike that in Western population, no study has examined the association between H. pylori infection and tooth loss. We examined 959 healthy adults who participated in a mass survey. We counted the number of residual teeth and measured both H. pylori stool antigen and serum anti-H. pylori antibodies. Serum pepsinogen levels were measured to determine the presence of atrophic gastritis. Multiple logistic regression analysis was performed after adjustments for age, body mass index (BMI), smoking and alcohol habits, and educational background. In men, H. pylori infection was a significantly reduced risk factor for loss of all the teeth even after adjustments for other factors (OR, 0.32; 95z CI, 0.12-0.81; P º 0.05). However, such an association was not found in women (0.91; 0.49-1.69). The calculated OR for the presence of atrophic gastritis among individuals with tooth loss was not significant in both men and women. H. pylori infection was associated with a decreased risk of tooth loss in healthy Japanese men.

Thirty three patients of cervical nodal metastasis from unknown primary were reported and discussed. They admitted Niigata Cancer Center Hospital since 1964 to 1983 .1. Limited to the twenty two patients who were treated by otolaryngological department , the incidence of unknown primary was 2.7%.2. In 6 cases primary sites were detected.Five cases of them were tumors of head and neck origine and another was a tumor of infraclavicular region origin.3. Histological diagnosis of metastatic nodes were squamous cell carcinoma (51.5%) carcinoma simplex and anaplastic carcinoma (24.2%) and the others (24.3%).4. Crude survival rate was 15.6% (3 year) and 10.0% (5 year).No one survived whose metastasis occurred in the supraclavicular lymph node and/or whose primary site was found after the initiation of the therapy. Difference of survival rate was not detected between neck dissection with radiation group and excision or biopsy with radiation group.

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