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AP = artificial pancreas; AT-III = antithrombin III; BG = blood glucose level; DIC = disseminated intravascular coagulation; ECA = endothelial cell activation; ECI = endothelial cell injury; GT = glucose tolerance; MODS = multiple organ dysfunction syndrome; mMOF = modified multiple organ failure; NIDDM = noninsulin-dependent diabetes mellitus; PAI-1 = plasminogen activator inhibitor-1; PLT = platelet count; PT = prothrombin time; SRH = stress related hormone; TAT = thrombin-antithrombin III complex; TM = thrombomodulin; tPA = tissue plasminogen activator; T 3 = triiodothyronine; T 4 = thyroxine.Available online http://ccforum.com/content/5/2/088 Abstract Background: Glucose tolerance (GT) has not been taken into consideration in investigations concerning relationships between coagulopathy and multiple organ dysfunction syndrome (MODS), and endothelial cell activation/endothelial cell injury (ECA/ECI) in septic patients, although coagulopathy is known to be influenced by blood glucose level. We investigated those relationships under strict blood glucose control and evaluation of GT with the glucose clamp method by means of the artificial pancreas in nine septic patients with glucose intolerance. The relationships between GT and blood stress related hormone levels (SRH) were also investigated.

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