Citation: Etindele Sosso FA, Hito MG, Bern SS (2017) Basic activity of neurons in the dark during somnolence induced by anesthesia. J Neurol Neurosci 8:3. AbstractAim:The first experience modulates the network of integration and memory in the sleeping cortex. Depending on the characteristics of this initial stimulation, the brain adjusts his electrical activity to respond during wake or sleep. This adjustment is different for every sub type of neurons and are influenced by the information drove by stimuli. Pyramidal cells and inhibitory cells behaviours after a short reminder during somnolence or sleep deprivation are still unclear.Materials and methods:Inhibitory interneurons and excitatory pyramidal cells in the primary visual cortex of anesthetized mice were stimulated in the dark after sleep deprivation of 12 hours. Analysis of electrical activity of sub-populations of neurons were performed with electrophysiological recordings.Results: A primary stability was revealed in the firing pattern. In the global sample, the discharge of inhibitory interneurons was the same before and after visual stimulation with induced-anesthesia somnolence. Absence of orientation in the stimuli didn't affected both inhibitory and excitatory activity. The findings also suggested the interplay between primary visual cortex and the short-term plasticity enhances during sleep. Conclusion:The conditions of the neurotransmission during wake or first stage of sleep prepares the mechanism of sleep-dependent plasticity. Stimuli properties affects the perception and memorization of new information, but the consolidation of their information is altered during sleep deprivation.