The hepatoprotective and antimutagenic effects of the rosemary essential oil and the ethanolic extract were investigated using carbon tetrachloride and cyclophosphamide as hepatotoxic and mutagenic compounds, respectively. Our results revealed that i.g. administration of the rosemary ethanolic extract (0.15 g/100 g BW) to rats for 3 weeks produced the most pronounced hepatoprotective effect compared to silymarin (reference compound) due to the amelioration of most of the studied serum and liver parameters and confirmed by histopathological examination of the liver tissue. Pretreatment of mice for 7 days with the rosemary essential oil (1.1 mg/g BW) followed by i.p. injection with cyclophosphamide reduced significantly the induced mitodepression in the bone marrow cells of the animals. The potential hepatoprotective and antimutagenic activities of the rosemary ethanolic extract and essential oil, respectively, are attributed to the presence of a relatively high percentage of phenolic compounds with high antioxidant activity (according to our chemical studies).

Wheat flour was substituted with soy protein isolate (SPI) at levels of 0-20% and its effect on aroma volatiles and quality of cookies was evaluated. The chemical analysis showed that the moisture and protein content increased gradually by increasing the added levels of SPI whereas the carbohydrate and fat levels showed the opposite trend. The sensory characteristics, aroma, taste, crispiness and overall acceptability showed significant (P < 0.05) increase of up to 10% SPI substitution compared with cookies free of SPI. The gas chromatographic-mass spectrometric (GC-MS) analysis of aroma volatiles revealed that the sample containing 10% SPI had the highest yield (13.57%) of pyranones, the key odourants of cookies. The results of GC-MS analysis were consistent with those of the aroma sensory analysis of cookies during storage.

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